You're an intelligent guy, but you're wrong.
Lo Celso needs to play as a 10. The whole team looks better when he is coordinating things from an advanced position. Ndombele has a place in the team, next to Hojbjerg - he would play instead of Winks.
Don't get me wrong, Ndombele is brilliant; capable of extraordinary skills, passes, through balls. But he works in moments of brilliance.
Lo Celso could drop deep in specific moments to open spaces for Ndombele to come from behind - but the Argentinian should be the one with the perrogative to do it (again, he truly understands how the team needs to work).
As for the defensive aspect of things, Winks is not developing - at least not yet - into the DM Jose would like him to be. He's got time on his side, of course. But at the moment, if Ndombele is doing his best - in matches and training - I don't think we would lose that much without the ball.
Hojbjerg + Ndombele, and Lo Celso as a 10.