With this being the line up in the home EL fixture 2 days later:
Aurier - Sanchez - Dier - Reguilon
Lo Celso - Winks
Lucas - Son - Lamela
I advise against lining up with 10 players in the strongest possible terms.
Seriously though, we cannot fuck around with Thursday. If any of these four fixtures demand a full-strength side, that one does. Doubly so if we lose Tuesday.
As much as I despise fielding joke lineups in cups, I thought Jose said it well after Shkendija when asked how he would rank the next three games, he said "the EFL ranked itself by putting the game 48 hours after a Premier League game and 48 hours before a knockout European game". That's totally correct IMO.