The central defence isn't actually bad but highly dependent on Stones staying fit. Both Guehi/Branthwaite is too young. Stones not in form but crucial to playing out and very experienced. At his best one of the best centre backs in the league.
The issue is definitely 6. Mainoo is going through a difficult phase (i think he's hugely talented but very raw) and so is Wharton. We straight up have a void here. We are far from the only international side to not have a traditional playmaking 6 but its a big gap.
Bellingham & Palmer could be the new Gerrard and Lampard - both best at 10, both going to be shifted out of position to get them on the pitch, both considered too good not to be in there.
Kane has 28 g/a in 19 league games and 7 CL goals. As much as he's a bit of a conundrum style wise these days, there isn't an objectively better centre forward in the world ... he will be picked.