Frank clearly has plethora of options in terms of the squad so that it is not easy to predict what formation he will pick out. That surely depends on the opponent which is West Ham and which I am not familiar with. The key problem Frank has is that not all players play every game in an uncompromising fashion. That's what I have noticed as the very most obvious thing with this Tottenham squad particularly in terms of Romero, Porro and Richarlison (Tottenham's Spanish/South American contingent). And, of course, others may join in and put in lackluster, weak and compromising performances. That I think is the key for him to figure out. Which players are ready and willing to give their utmost best in every single moment of every single game. That is I think his key problem. Not how to deal with opponents and what strategy to pick out. But how to deal with and manage his own players and team.
Last year with Brentford Frank utilized 4-2-3-1 when playing West Ham away. And he got a 0 : 1 win for his Brentford side.
Thinking about 4-2-3-1 formation I think Frank will/should go for this:
. . . . . . . . . . . . . . . Vicario
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Spence
. . . . . . . . . . . Sarr . . . . . Palhinha . . . . . . . . .
. . Kudus . . . . . . . . . Xavi . . . . . . . . Johnson
. . . . . . . . . . . . . . Kolo Muani . . . . . . . . . . . . .