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Transfers Summer 2019 transfer thread

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Got a bit defensive at the end, it's not one study and not my fault you are not aware of this emerging field of research. It's a really solid collation of studies, think you are being mean spirited towards it.

I edited the original post to say Omega3/6 (as that paricular point in that study was N6, but they are a tandem as I am sure you are aware, but it is not as simple as N3 good, N6 bad.

I've worked with a Nobel winner, on their prize winning work, as it happens, not that it makes me any more informed than anyone else on these new study areas.

Next you'll be saying the terrain pH doesn't matter either...
Thanks, doc. Wanna get a drink later?
 
I’m just disagreeing with the notion that it’s “evident” that RB/Trippier is our biggest problem/weakness. It isn’t. Having a RB that isn’t the best in the league but is still decent (you do realise Walker was shelved by Guardiola midway for repetitive mistakes and poor performances) is much less of a weakness than having one of the shittest midfields in this league.
I said he was 'a weak link in our side' - not our biggest weakness.
:sonhmm:

Man City have an embarrassment of riches, so them benching Walker isn't the biggest shocker. For what it's worth, I knew he'd regress there as Poch has repeatedly shown himself to be a full-back whisperer. Makes me wonder what Trippier will be like in a year if/when he moves on.

Anyway, we don't seem to disagree that Ndombele through the door ASAP is priority!
 
Everyone knows it's Omega3/6 and Bacteria based now... But stress will definitely strain the adrenals and set the scene.

H.Pylori, for example, is demonstrated to be regulated down by ALA and L.Plantarum, deep stuff.

"Physiological functions of CLA and HYA. CLA and HYA are produced from linoleic acid by intestinal bacteria. c9,t11-CLA ameliorates insulin sensitivity and prevents atherosclerosis, t10,c12-CLA deteriorates insulin sensitivity and promotes atherosclerosis, and t9,t11-CLA prevents atherosclerosis. HYA enhances intestinal barrier function by increasing occludin expression and inhibiting intestinal inflammation in a GPR40-dependent manner. HYA inhibits atopic dermatitis by increasing claudin-1 expression and enhancing skin barrier function. HYA also inhibits gastric Helicobacter infections by blocking the bacterial futalosine pathways. "



Not deep enough and wrong in conclusion = https://www.researchgate.net/public...ogical_factors_of_duodenal_and_gastric_ulcers

"The most common cause of duodenal and gastric ulcer was Helicobacter pylori, and it was responsible for three-fourths of the cases. About half of the patients had a history of nonsteroidal antiinflammatory drug use, and nonsteroidal antiinflammatory drug and Helicobacter pylori were both responsible for the ulcer in three-fourths of these patients. In about one-tenth of the patients, nonsteroidal antiinflammatory drug use was the cause of ulcer alone, and about one-tenth of the ulcers were classified as idiopathic. "

Given the above, you can see the H.Pylori blaming is foolish, dated thinking. Trigger yes, cause no. Béchamp looking pretty smug nowadays, to me.

(Bored on nights)
This quite correct. Well posted
 
What does this have to do with anything? I asked about the implication of Omega 3s. N6 would be for Omega 6s. And thus if you are suggesting that since an N6 inhibits (probably in vitro) these things then N3s must be bad? But even taking this as 'fact' for now that wouldn't support the statement that Omega 3s are an etiological agent. ie if one thing is protective it doesn't automatically mean the other detrimental. And to claim that something is an etiological agent then by definition it has to be detrimental. And again, I would like to add that this looks to all have been done IN VITRO and 1 study. If you only knew how many types of cancer I 'cured' in cell culture by soaking them in different eicosanoids you would be amazed...except that every grad student in the biomedical sciences has done similar. None of this actually means anything in vivo and it's a far cry from being accepted scientific fact to suggest etiology.


This is not how anyone would do this in a disease state situation. How is it do you think someone gets H pylori in their gut?


Actually the jig was up when you capitalized the 'p' in pylori. The use of individual studies from questionable journals was just confirmatory. You'd be surprised what gets published and why. Quite frequently things get published because they are the first to do it/demonstrate a certain thing. That thing may not be useful or further science much but the important thing is that now it is 'known'. In the publish or perish world of big academia there is a lot of noise to sift through to get to the real science.
Has this something to do with football transfers?
 
I said he was 'a weak link in our side' - not our biggest weakness.
:sonhmm:

Man City have an embarrassment of riches, so them benching Walker isn't the biggest shocker. For what it's worth, I knew he'd regress there as Poch has repeatedly shown himself to be a full-back whisperer. Makes me wonder what Trippier will be like in a year if/when he moves on.

Anyway, we don't seem to disagree that Ndombele through the door ASAP is priority!

Fair do’s. Looking back, you are right, you didn’t say he was our biggest weakness. My bad. As you were.
 
Fair do’s. Looking back, you are right, you didn’t say he was our biggest weakness. My bad. As you were.
It's no worries.

For me: the list (in rough priority order) is...

CM/CDM - so Ndombele, ideally.

CAM - in the Lo Celso/Fernandes mould: didn't think this would be done without Eriksen leaving but the transfer rumour mill makes it sound like we want another player like that regardless.

RB with Trippier and/or Aurier out.

CB replacement if Toby leaves.

Sessegnon and Clarke feel like bonuses, really.
 
Yeah, we were just wondering if we should have Ndombele do a CLO during his medical or just stick with the breath test. I was thinking he should do the GFY test. Perhaps you should too?

Told you Todd, it doesn't matter, as long as we wang him on the Flax upon signing, and Son can give him some Kimchi for a plentiful supply of L.plantarum (lower case, check me out!).

:tobyarm: (just discovered these, trying to keep it jovial, looking for a simple smile)
 
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giphy.gif

Lyon make an official bid for Anderson - who knew that was coming? Not Ron obviously .....

Lyon enter race for Anderson
 
Hope the Toby situation clears up soon

Think Toby and Eriksen are what's holding a lot of our transfers back, once those decisions are made then things will get moving for us ...

Same across Europe - Hazard done, De Jong done, Hernandez done, Jovic done now just waiting on Pogba, Bale, De Gea, Griezmann, Felix, Coutinho, De Ligt, ... once these 100m plus moves happen then the whole market kicks into overdrive ... but until that billion dollars gets spread around patience remains the key ....
 
If we're anywhere close to willing to splash near £70 mil. on someone like Lo Celso, then I'd much rather take a punt on Kai Havertz from Bayer Leverkusen. Test their resolve. Kids pure class.
 
"HYA also inhibits gastric Helicobacter infections by blocking the bacterial futalosine pathways. "

N6 is actually what the body converts into HYA = 10-hydroxy-cis-12-octadecenoic acid.

If you are medical, of course you will look at H.Pylori, but looking at it from a biochemistry viewpoint it is further back along the regulatory chain which makes the host susceptible, or as I see it the real cause.

I'm a very, very amateur scientist (emphasis very, very)...

Edit : Fledgling research areas, but here are some further:

Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid (HYA), alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice.


Japan leading on this stuff it seems.

More:

Highlights

• A gut microbial metabolite of linoleic acid (HYA) elicits anti-inflammatory effects in vitro

.• HYA down-regulates the Lipopolysaccharide-induced maturation of bone marrow dendritic cells (DCs).

• HYA treatment associated with an anti-inflammatory profile in murine enterocyte and in mature DCs.

• HYA up-regulates cytoprotections in murine enterocyte and in mature DCs.

• HYA is considered a functional component in foods and pharmaceutical products.


Anyway, hope NDombele has a good dietary lipid profile... :)

Bad nonce
 
Apologies - I mistyped and meant 15/16 (and 16/17).

As for Trippier apparently playing the last months of that 16/17 season, here's a list of the final 17 Premier League games of that year and the starting RB/RWB...

Man City - Walker
Sunderland -Walker
Middlesborough - Walker
Liverpool - Walker
Stoke - Walker
Everton - Walker
Southampton - Walker
Burnley - Trippier
Swansea - Walker
Watford - Trippier
Bournemouth - Walker
Palace - Walker
Woolwich - Trippier
West Ham – Walker
United - Trippier
Leicester - Sissoko
Hull - Trippier

It took until April 1st for Trippier to take any foothold as our starting right back, probably in no small part because by that point we didn't have many cup games to use him. Even then, they still alternated - 5 Trippier starts to Walker's 4 and bloody Sissoko ended up being wheeled out as a RWB against Leicester.

According to Poch's book, it was after the Watford game that Walker came to him and asked to leave. Again, this makes me very unsure as to what exactly the motivation was over team selection at RB from that point on. My best bet is rotation for fitness with Trippier getting the more prestigious games.

Regardless, our best performing league season - that of 16/17 - came with Walker as our clear first choice RB and it's erroneous to use that 2nd place finish as any justification as to why Trippier is good enough.
Take out the 2nd season if you want.....he has finished 3rd and 4th as first choice.

It’s not his fault the forwards have bottled crunch games over those seasons.

The 2nd season we had the “superior RB” who people think would have made such a major difference to us recently.
However we lost the title.....to Leicester, won fuck all, did nothing in Europe.
He scored 5 goals (Stoke, WBA, Burnley, Everton, Hull) and got zero assists.

So again, how is the RB the issue?
26 shots and no goals in a 1-0 home defeat to Leicester which would have put us 1pt behind them was the reason we didn’t win the PL.

So, again, look towards Kane, Dele and Eriksen, because it’s still the same problem 3 years later.
People are just blinded to it, Poch included.
 
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Has this something to do with football transfers?

Really enjoyed re-reading old notes last night, personally just wanted to give Todd a little dig as I have been observing him "giving it large" to Airfixx Airfixx (who likes quite a few of my posts, so naturally I have an affinity to!).

Psychology, and the basis of GC MAF :levywhoa: in the Transfer Thread (Actually my thinking about it started with a Stress Management Training course a few years ago, where the lecturer asked us "Why does the Zebra not get Ulcers?", back then the room gasped when I raised my hand and said "the Zebra must not be susceptible to H.pylori". Anyway... Airfixx said about stress and ulcers... Todd gave him a dig about it adding to his list...)

(at 10:01am on a Saturday morning, with my wife feeding my daughters a Budwig blend of Flax and Kefir Quark - Good Fats and which block bad Bacteria and nourish good, things are feeling pretty cool, gon b no nagalase in my kids).

Sorry everyone uninterested (so, just about everyone!)
 
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