If I'm Tim I'm developing two different squads for the league and EL. We have enough depth to run out a team fully made up of 1st teamers in Europa without a single one having to play in the weekend fixture. Lloris would be the only one I would play in back to back fixtures. Though we might have to be a little more flexible in the short term with a couple of injuries.
Still would rather not see any of Walker, Kaboul, Vertonghen, Rose, Paulinho, Dembele, Eriksen, Bentaleb, or Adebayor involved in EL at the moment. Our squad and younger players are hungry for appearances and Europa is perfect for them to gain fitness and impress. Hoping to see Soldado, Townsend (getting back into match sharpness), Capoue (get fitness), Naughton, Fryers, Sigurdsson, Chadli, Veljokvic, Kane, maybe even Lennon or Sandro if he needs a game.
Due to a couple of injuries we have may have to play a couple of starters but I'd rather not see more than 1 or 2 play. Our squad is massive and has talent. Got to get the fringe players games to keep them fresh and happy and protect the first them for the league. If we get to the quarters we could start putting in more starters but for now I'd prefer if we didn't.