Right back, centre half and defensive mid are priorities for sure.
Aurier needs to go. He is causing more issues than he is solving. Vertonghen will also go I think, and Rose. Foyth I imagine will be sold.
If we can get a new right back and defensive mid we are on the right path. Jose is reknowned for having a defensive midfield next to a player who can make the pass (Matic and Pogba/Herrera at Man Utd, Matic and Fabregas and Makekele and Lampard at Chelsea, Khedira and Alonso at Madrid.)
As for centre half, I think Tanganga and Sanchez could be a solid pairing but still think we need more cover. Is Dier, Alderweireld, Sanchez and Tanganga enough? I don't think so.
I wouldn't be surprised to see Lamela, Aurier, Foyth, Rose all leave permanently, Skipp and Amos on loan and if the right bid comes in maybe Sissoko (although I think he could play a part next season)