As far as Ange's future here is concerned, he can't afford to let the league campaign go in its entirety by putting all his eggs in EL basket. Because in such a scenario, if he for whatever reason fails to win EL he would have no ground left to stand on. Definitely a high reward, but one that comes with a very high risk. I know he's not the most risk averse person in general, but he'd still be better off with a more balanced allocation of resources between those two campaigns. Whatever that entails in practice.
So the way I see it, his self-interest does not perfectly align with what would be the best for the fans and the club in general. Unless he has some sort of a guarantee that he's here next season no matter what, I'd be shocked to see him throw league matches away by sitting most of his regulars.