It entirely dependant on the role the player is being asked to play in the team. For example, I would rather play Dier at CB than Messi.
If we take Nuno's 3st 1 games as an example, we are playing a midfield 3 of PEH - SKIPP - DELE
Dele is playing box to box and covering the left of midfield. Full licence to press forward when we have the ball.
PEH and Skipp have less free licence to push forward. Skipp is focused around the center of the pitch, playing as 'rat catcher' - chasing down players and nipping at their heels. Whereas PEH drops deeper to block shots and help out the center backs.
If Ndombele plays he isn't going to be chasing balls, he wants PEH and another defensive midfielder to do this for him - and with no GLC/Skipp, Winks is our only clear option in this area.