It's easy to disagree with the headline of thread, as no one wants to 'sacrifice' PL, but would you really go for option 1 or 2 above??Look at the fixture list in OP.
There's 3 options when it comes to Kane/ Son/ Ndombele:
1/ Never rest them for rest of season (would probably lead to fatigue and injury unless we exited EL early)
2/ Rest them for a Europa League Knock-out tie (given all remaining teams are of decent standard, this would increase chance of early exit in any round)
3/ Rest them in some PL games, so they can play all Europa League K/O ties.